Never Out is trained by Kim Waugh whose husband Mark played 128 tests for Australia and is now a national selector.
She jumped smartly and raced up on the pace for Mitchell Bell before kicking clear to win the 1000 metre maiden by three quarters of a length.
The three-year-old filly's ownership includes Mitch and Shaun Marsh who played in Australia's recent defeat by South Africa in the first Test in Perth, as well as white-ball specialists Glenn Maxwell and Aaron Finch.
Former Test players Greg Blewett and Ryan Harris also have a share along with national coach Darren Lehmann's wife Andrea and broadcaster Alan Jones.
The horse was named Never Out as a tribute to Hughes who died after he was hit by a ball while 63 not out in a Sheffield Shield match in November 2014.
"We bought the horse in memory of Phillip Hughes," Mark Waugh told Sky Thoroughbred Central.
"We got together to all buy a horse because he used to love horse racing so she might have had a bit of help today."
A $57,500 Inglis Classic purchase from the Amarina Farm draft for Kim Waugh Racing, Never Out is the fifth winner from stakes-placed Rory's Jester mare Jesterchine.
She is another smart winner for Star Witness, who has been riding high this spring thanks to brilliant three year-olds Global Glamour and Star Turn.